Acute Toxicity Study and Comparative effect of Kigelia Pinnata (Cucumber Tree) Ethanolic leaf extract on Serum Lipid profile of Albino Wistarrats treated fat diet.

Authors

  • C I Tarnande Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria.
  • F Uboh Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria.

DOI:

: https://doi.org/10.46912/napas.39

Keywords:

Kigelia Pinnata, Hyperlipidaemia, Hypolipidaemia, Lorke's method

Abstract

The aim of this study was designed to evaluate the activity of the Kigelia Pinnata ethanolic leaf extract on the serum lipid profile of male albino Wistar rats exposed to a fat diet. Kigelia Pinnata leaves were obtained, air dried, powdered and extracted in a Soxhlet apparatusin 400ml ethanol solution. Hypolipidaemic activity studies on rat models fed with palm oil and coconut milk was conducted. The acute toxicity test of the extract was carried out by the lorke's method. Results showed that Kigelia Pinnata ethanolic leaf extract significantly lowered (P<0.05) plasma Total Cholesterol (TC), Low Density Lipoprotein (LDL)-Cholesterol and Triacylglycerol (TG) and significantly (P<0.05) increased plasma High Density Lipoprotein (HDL)-Cholesterol. Toxicity studies suggested that, the extract was safe at the doze 2000mg/kg. Overall findings from this study showed that the ethanolic extract exhibited hypolipidaemic activity and may possess cardio-protective properties.

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Published

2019-03-14

How to Cite

Tarnande, C. I., & Uboh, F. (2019). Acute Toxicity Study and Comparative effect of Kigelia Pinnata (Cucumber Tree) Ethanolic leaf extract on Serum Lipid profile of Albino Wistarrats treated fat diet. NIGERIAN ANNALS OF PURE AND APPLIED SCIENCES, 1, 144–152. https://doi.org/10.46912/napas.39

Issue

Vol. 1 (2018): Maiden Edition of NAPAS

Section

Original Article