Effects of Dombeya Buettneri Extracts on Heamapoietic Indices of Wistar Albino Rats

Authors

  • G O Obochi Department of Biochemistry, Benue State University, Makurdi
  • D O Ochalefu Department of Biochemistry, Benue State University, Makurdi
  • E O.O Amali Department of Biochemistry, Benue State University, Makurdi
  • N Ufaruna Department of Biochemistry, Benue State University, Makurdi
  • B Myke Mbata Department of Chemical Pathology, Benue State University, Makurdi
  • M U Eteng Department of Biochemistry, University of Calabar. Calabar

DOI:

: https://doi.org/10.46912/napas.7

Keywords:

Dombeya buettneri, heamapoietic indices, wistar rats, electrolytes

Abstract

The effects of Dombeya buettneri extracts on electrolyte and heamapoietic indices of wistar albino rats were studied. The results showed that there was a significant increase in red blood cells, white blood cells and hemoglobin, resulting in hemopoiesis and synthesis of hememoiety for hemogloglobin. The
phytochemical composition showed low phytic acid (trace) which suggests antioxidant activity, enhancing immunocompetence. The LD50 obtained was 2.58mg/kg, suggesting that dosage of Dombeya buettneri below this LD50 is safe. This work suggests that Dombeya buettneri may be useful in
the treatment of anemia and may boost immune response, and that administration (dosage) below 2.58mg/kg is safe

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Published

2015-12-28

How to Cite

Obochi, G. O., Ochalefu, D. O., Amali, E. O., Ufaruna, N., Myke Mbata, B., & Eteng, M. U. (2015). Effects of Dombeya Buettneri Extracts on Heamapoietic Indices of Wistar Albino Rats. NIGERIAN ANNALS OF PURE AND APPLIED SCIENCES, 6, 41–49. https://doi.org/10.46912/napas.7

Issue

Vol. 6 (2015)

Section

Original Article